Whereas there is significant overlap and multiplicity in the various training programs, the research faculty are listed below according to their primary departmental affiliation except for the Program in Developmental Genetics, which comprises members of the Departments of Biology at the main campus (indicated by *) and Cell Biology at the School of Medicine.

BIOCHEMISTRY

Bar-Sagi: Ras signaling, growth control, inflammation, and cancer. Borowiec: stress-dependent regulation of the cell cycle. Cowan: protein folding in the eukaryotic cystosol. Hong: mechanisms of axon guidance and synaptic modification. Huang: deubiquitination in DNA repair and cancer. Klein: genomic instability of DNA damage checkpoints. Kong: structural studies of DNA replication proteins. Lee-Huang: novel anti-HIV and antitumor agents. Nudler: mechanisms of transcription elongation and its regulation. Reinberg: gene expression. Ziff: molecular mechanisms of synaptic regulation.

CELL BIOLOGY

Adesnik: control of exocytotic and endocytic protein transport. Brooks: regulation of invasive cellular processes. Brown: bioinformatics. Chao: mechanisms of neurotrophin receptor signaling. Cowin: cell adhesion and Wnt signaling. Fishman: ovarian metastasis, regulation of ovarian metastasis, proteomics, cellular motility, matrix metalloproteinases, lysophospholipids. Frey: T cell immune responses. Gutstein: molecular cardiology. Kluger: bioinformatics. Kreibich: synthesis, assembly, and sorting of membrane proteins. Mignatti: molecular mechanisms of angiogenesis. Munger: regulation of TGF-ß activity by integrins. Nance: morphogenetic movements that occur during development. Orlow: molecular and cellular basis of pigmentation. Philips: membrane targeting of GTPases. Reinberg: gene expression. Rifkin: control of TBF-ß presentation in normal and pathophysiology. Ron: cellular adaptations to unfolded and malfolded proteins. Ryoo: study of apoptosis using Drosophila models. Sabatini: protein sorting in eukaryotic cells. Salzer: axon-glia interactions in myelinated nerves. Stokes: structural studies of ion pumps and adhesive junctions. Wang: structural studies of membrane transporters. E. Wilson: basic fibroblast growth factor in hematopoiesis.

DEVELOPMENTAL GENETICS

Burden: signaling at the vertebrate nerve-muscle synapse. Dasen: control of neural identity and connectivity in vertebrates. Dasgupta: dissection of the Wnt/wingless signaling pathway using functional genomics and proteomic approaches. Fishell: mechanisms of neural patterning in mammalian forebrain. Fitch*: developmental genetics of tail development in C. elegans. J. Hubbard: gonad development in C. elegans. Lehmann: germ line development in Drosophila. Loomis: molecular mechanisms underlying skin and limb patterning. Nance: morphogenetic movements that occur during development. Rushlow*: dorso-ventral axis formation in Drosophila. Ryoo: study of apoptosis using Drosophila models. Small*: segmentation in Drosophila. Torres-Vazquez: mechanisms of regulation of blood vessel growth. Treisman: pattern formation in the Drosophila visual system. Yelon: patterning the zebrafish heart.

MEDICAL AND MOLECULAR PARASITOLOGY

Carlton: comparative genomics of parasites. Clarkson: parasite biochemistry, cell biology, and chemotherapy. Day: malaria. Eichinger: pathogenic mechanisms of protozoan parasites. Frevert-Clarkson: molecular interactions of malarial sporozoites and host cells. Nardin: mechanisms of immunity to malaria parasites. Raper: African trypanosome lytic factors: novel mediators of human innate immunity. Rodriguez: malaria liver infection and initiation of immune response. Sinnis: cell invasion by Plasmodium sporozoites.

MICROBIOLOGY

Basilico: cell proliferation control in normal and cancer cells. Belasco: posttranscriptional gene regulation. Blaser: the biology of bacterial persistence in mammalian hosts. A. Darwin: genetic analysis of Yersinia enterocolitica virulence. K. H. Darwin: TB pathogenesis. Derkatch: biogenesis, variability, and physiological role of prions. Ernst: immunity to tuberculosis. Garabedian: signal transduction and transcriptional regulation by steroid receptors. Hanna: clinical microbiology and the challenge of tuberculosis. Laal: pathogenesis of M. tuberculosis infection in humans. Landau: HIV infection and AIDS. Littman: T lymphocyte development and retroviral pathogenesis. Mansukhani: FGFs and FGF receptors in development and oncogenesis. Mohr: interactions between herpes viruses and their host cells. Novick: molecular basis of virulence in Staphylococcus aureus. Perez-Perez: epidemiology and pathophysiology of enteric bacterial infections. Schneider: altered regulation of gene expression in carcinogenesis and cell stress. Tanese: transcriptional regulation in eukaryotes. Unutmaz: HIV-T cell interactions. Vilcek: mechanisms of cytokine actions. A. Wilson: viral control of cellular proliferation.

PATHOLOGY

Aifantis: control of exocytotic and endocytotic protein transport. Bar-Sagi: Ras signaling, growth control, inflammation, and cancer. Basch: regulation of stem cell growth and differentiation. Bhardwaj: immunobiology of antigen presenting cells. Burakoff: mechanisms of signaling pathways. Cho: investigating novel therapeutics targeting type 1 MAGE in myeloma. Cronstein: adenosine receptors in health and disease. Demaria: fundamental and translational studies of breast cancer. Dustin: formation and regulation of the immune synapse. Erlebacher: mechanisms of maternal immune tolerance towards the allogeneic fetus. Ghiso: role of amyloid deposits in neurodegeneration. Gold: mechanisms of escape from growth regulation in hormone-driven cancers. Hanna: clinical microbiology and the challenge of tuberculosis. Hernando: molecular mechanisms underlying the neoplastic transformation process. Hioe: role of antibodies in HIV immunity and pathogenesis. Krogsgaard: sensitivity of T cell activation. Lafaille: molecular pathogenesis of autoimmune and allergic diseases. D. Levy: cytokine signaling; signal transduction, and gene expression. Littman: T lymphocyte development and retroviral pathogenesis. Meruelo: genetic predispositions to tumorigenesis and potential treatments. Newcomb: molecular genetics of human cancer. V. Nussenzweig: immunobiology of intracellular protozoan parasites. Nyambi: genetic and antigenic relatedness of HIV Type 1. Ostrer: genetic basis of disease. Pagano: cell cycle control and cancer. Pellicer: molecular alterations in tumor formation. Roth: V(D)G recombination, DNA repair and lymphomagenesis. Skok: nuclear organization of immunoglobin genes. S. Smith: mechanisms of telomere function. Teebor: molecular genetics and enzymology of DNA excision repair. Trombetta: denditric cell function in innate and adaptive immunity. Turnbull: in vivo microimaging of transgenic mice. Zolla-Pazner: development and characterization of human monoclonal antibodies.

PHARMACOLOGY

Bach: roles of the Jak-STAT pathway in Drosophila. Burden: synapse formation. Cardozo: development of computational tools targeted at visualizing and engineering 3D structural features of molecules. Carr: neurobiology of ingestive behavior and drug addiction. Dasgupta: dissection of the Wnt/wingless signaling pathway using genomic and proteomic approaches. David: chromatin modification and its impact on regulation of gene expression and nuclear structure. Gardner: mechanism and significance of hypoxic regulation of the cell cycle. S. Hubbard: structural studies of receptor tyrosine kinases. E. Levy: molecular pathology of cerebral amyloidosis and hemorrhage. Logan: growth regulation through the androgen receptor. Margolis: structure and functions of nervous tissue proteoglycans. Mohammadi: structural and functional studies of fibroblast growth factor (FGF) receptor regulation. Neubert: analysis of proteins by mass spectrometry. Reinberg: gene expression. Reith: structure, function, and regulation of the dopamine transporter. Samuels: transcriptional regulation by nuclear receptors. Simon: neuropeptides and their receptors. Skolnik: insulin receptor and MAP kinase signaling pathways. Stanley: insulin-increased gene transcription. Sun: keratins as markers for epithelial differentiation. R. Xu: structural studies of gene expression and epigenetic inheritance. Yamasaki: retinal blastoma tumor suppressor.

PHYSIOLOGY AND NEUROSCIENCE

Axel: cardiovascular MR imaging. Baker: neurogenetic behavioral physiology of developing brainstem postural and gaze control systems. Blanck: volatile anesthetics modify Ca2+ homeostasis. Bloomfield: propagation and integration of visual signals in mammalian retina. Chen: development of magnetic resonance imaging (MRI) radiology techniques. Chesler: regulation and modulation of pH in the brain. Coetzee: potassium channels in the cardiovascular system. Dasen: control of neural identity and connectivity in vertebrates. Duff: mechanisms involved in the pathogenesis of neurodegenerative diseases. Gan: structural plasticity of synapses in vivo. Gardner: sensory functions of the hand. Ginsberg: neurodegeneration and lesion-induced synaptic plasticity. Gonen: functional MRI on human brains. Grossman: magnetic resonance evaluation of multiple sclerosis. Helpern: magnetic resonance imaging of the brain. Hillman: molecular organizations; neuronal integration and synaptic plasticity. Holz: molecular physiology of stimulus-secretion coupling. Inglese: quantitative MRI in multiple sclerosis. Javitt: cognitive/ neurophysiological abnormalities in schizophenia. Jensen: quantitative MRI in brain and liver; development of MRI techniques to measure tissue/ organ function. Johnson: mathematical models on the effect of microscopic magnetic field inhomogeneities on NMR signal decay. Kao: dementia. Kolodny: neurogenetics, lysosomal diseases, and gene therapy. Laflen: mathematical modeling of human auditory perception. Lang: neuronal basis of motor coordination. V. Lee: functional body and cardiovascular MRI. Llinás: intrinsic properties of neurons. Mathews: role of endosomal-lysosomal system in neurodegeneration (Alzheimer’s disease). Morley: conduction of electrical impulses in the heart. Rice: neurochemistry and neurophysiology of dopamine and CNS antioxidant network. Rosenbluth: pathology of dysmyelination and demyelination. Rudy: molecular mechanisms regulating neuronal excitability. Simpson: sensorimotor integration, eye movements, and the cerebellum. Sugimori: ionic mechanism of the cerebellum Purkinje cell. Walton: postnatal development of the mammalian nervous system. T. Wisniewski: pathogenesis of Alzheimer’s disease and other cerebral amyloidoses. Witkovsky: dopamine-induced modulation of retinal function.

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